How are exacerbations and complications of factor XIII (FXIII) deficiency prevented?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Avoidance of high-risk activities (eg, boxing, motorbike riding) and NSAIDs reduces the frequency of bleeding.

Avoidance of alcohol helps protect liver function in patients with hepatitis.

Primary prophylaxis is the best way to prevent recurrent CNS bleeding, recurrent miscarriages or, rarely, recurrent joint bleeding. Joint replacement may be needed in the older patient with severe arthropathy. 

Carcao et al reported that in patients with congenital FXIII A-subunit deficiency, prophylaxis with recombinant factor XIII-A2 (rFXIII-A2) provided sufficient hemostatic coverage for minor surgery without the need for additional FXIII therapy. Minor surgery was performed as long as 10 to 21 days after the last dose of rFXIII-A2. [127]

HAV and HBV vaccines should be administered. Other routine vaccinations, such as those for influenza and pneumonia, should be provided as in other persons.

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