What is the role of NSAIDs in the treatment of factor XIII (FXIII) deficiency?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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In recent years, the use of NSAIDs to relieve pain has increased in patients with bleeding disorders. Although they provide relief from inflammatory pain, patients experience increased GI tract or other bleeding because of the impact of the drugs on primary hemostasis, and they require additional FXIII replacement to control bleeding. The problem is magnified by the availability of over-the-counter NSAID pain relievers. Non-NSAIDs, such as acetaminophen and codeine-type analgesics, are much less effective, and some are addictive.

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