What are the reported uses of factor XIII (FXIII) in unusual circumstances?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Several reports exist of the use of FXIII in unusual circumstances. Note the following:

  • Effectiveness of normalizing FXIII levels in the treatment of a cerebrospinal fluid leak, which started 2 weeks after removal of a meningioma, was reported in a Japanese patient. [110]

  • The potential use of transglutaminases to mechanically stabilize and allow cultured epithelial autografts to take when used to repair extensive skin wounds supports a possible role of FXIII in the formation of de novo dermoepidermal junctions, thereby facilitating permanent skin replacement. [110]

  • Improved stability of surgical wounds has been reported following infusion of FXIII concentrates.

  • Although a few reports exist concerning the use of FXIII replacement in patients with scleroderma, Henoch-Schönlein purpura, and malignancies, the value of such replacement therapy remains to be established by proper clinical trials. [11, 111, 112, 113]

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