What is included in the initial workup of factor XIII (FXIII) deficiency?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

The following routine tests are the first step in the evaluation of any bleeding disorder:

  • Activated partial thromboplastin time (aPTT)
  • Prothrombin time (PT)
  • Thrombin-clottable fibrinogen level
  • Platelet count
  • Bleeding time (after ascertaining that the patient was not on antiplatelet drugs for at least the preceding 5 d)

However, these tests cannot be used to screen for FXIII deficiency because the results would be within reference ranges in a patient with isolated severe FXIII deficiency, [4] and blood collection, transport, and storage may alter results for these initial screening tests. [96]


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