Which conditions are included in the differential diagnoses of factor XIII (FXIII) deficiency?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Other problems to be considered in the differential diagnosis include the following:

  • Factor XIII (FXIII) alloantibodies (which can be a cause of bleeding in patients with inherited severe FXIII deficiency who receive FXIII replacement)

  • Rare inherited afibrinogenemia or dyshypofibrinogenemias associated with a bleeding disorder

  • a2 -Plasmin inhibitor deficiency

  • Plasminogen activator inhibitor-1 deficiency

  • Hemophilia A or B (should be excluded, particularly in a male with delayed onset, recurrent bleeding after trauma or surgery, or with a joint bleed)

  • Bleeding in a patient with type III von Willebrand disease (may mimic hemophilic bleeding)

  • Inherited severe bleeding disorders affecting platelet function, eg, Glanzmann thrombasthenia

  • All other rare coagulation factor deficiencies (FII, FV, FVII, FX); all of these factor deficiencies are associated with abnormalities in routine screening coagulation tests (eg, activated partial thromboplastin time [aPTT], prothrombin time [PT]).

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