Which physical findings are characteristic of factor XIII (FXIII) deficiency?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Physical findings depend on the site at which bleeding develops and include the following:

  • Bleeding from the umbilical cord in neonates usually manifests with persistent oozing, which may start a few days after birth.

  • Findings associated with CNS bleeding depend on the location of the bleeding. Trauma may precede the event, with additional findings. A new CNS bleed may be superimposed on residual findings related to a prior bleed.

  • Findings in patients with bruising and soft tissue bleeding are similar to those seen in other patients with coagulation disorders; it is uncommon to find the large hematomas or joint bleeds characteristic in patients with severe hemophilia.

  • Patients may present with vaginal spotting or bleeding during early pregnancy, preceding a spontaneous miscarriage.

  • Persistent, delayed, or recurrent bleeding may occur at sites of trauma or surgery.

  • Poor wound healing may be noted.

  • Acquired causes of FXIII deficiency, such as disseminated intravascular coagulation (DIC) and liver disease, present in a well-recognized manner.

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