What is the role of factor XIII (FXIII) deficiency in the pathophysiology of degenerative brain disorders?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

An unexpected role has been postulated for FXIII in degenerative brain disorders. In Alzheimer disease and spongiform encephalopathies, the brain contains fibrils that develop from native proteins containing a discordant a helix. Human FXIII was found to form fibrils in buffered saline, suggesting that FXIII, in addition to several other proteins, can be a source of this abnormal fibrillar protein. [63]


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