How does factor XIII (FXIII) deficiency affect wound healing?

Updated: Mar 09, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Physiologically, hyperpermeability induced by severe metabolic inhibition of porcine aortic endothelial cells is prevented by FXIIIa, which is similar to the maintenance of endothelial barrier function by FXIIIa despite depletion of energy or during reperfusion of ischemic rat hearts. [48] In a different system, FXIII induced epithelial wound healing by increasing cell growth by approximately 2.5 fold, leading to replacement of damaged cells. [49] Smooth muscle cell migration, an integral part of the healing process, is facilitated by FXIII. Migration of smooth muscle cells in cross-linked fibrin gels was twice the migration seen in non–cross-linked gels, demonstrating the importance of the 3-dimensional clot structure created by cross-linking in smooth muscle cell migration. [50] In humans, Fibrogammin was shown to contribute to the healing of venous leg ulcers by reducing endothelial permeability. [51]

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