Which replacement factor XIII concentrates are used in the treatment of factor XIII (FXIII) deficiency?

Updated: Apr 02, 2018
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

FXIII concentrates for replacement are as follows:

  • Plasma-derived virus-inactivated human FXIII concentrate (Corifact, in the United States; Fibrogammin P in Europe, South America, South Africa, and Japan); a second FXIII concentrate (Bio Products Laboratory, Elstree, Hertfordshire, UK) is available on a per-patient request

  • Recombinant FXIII A-subunit, recombinant (Tretten)

Minor bleeding, as from cuts and abrasions, may respond to conservative measures, such as pressure, ice, and use of antifibrinolytic drugs. Avoidance of trauma and nonsteroidal anti-inflammatory drugs (NSAIDs) is helpful in reducing bleeding events.


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