What is included in the qualitative screening test for severe factor XIII (FXIII) deficiency?

Updated: Apr 02, 2018
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Assessment of clot solubility in 5M urea or 1% monochloroacetic acid

Lysis of thrombin and Ca2+ - induced clot within a few hours suggests severe FXIII deficiency, provided that fibrinogen levels are qualitatively and quantitatively within reference range

The thrombin-clottable fibrinogen test can be used to exclude hypofibrinogenemia and dysfibrinogenemia, which cause false-positive results on the 5M urea solubility test


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