How does the site of bleeding affect the physical findings of factor XIII (FXIII) deficiency?

Updated: Aug 01, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Physical findings depend on the site at which bleeding develops and include the following:

  • Bleeding from the umbilical cord after birth usually manifests with persistent oozing, which may start a few days after birth

  • Findings associated with CNS bleeding depend on the location of the bleeding; trauma may precede the event, with additional findings, a new CNS bleed may be superimposed on residual findings related to a prior bleed

  • Findings in patients with bruising and soft tissue bleeding are similar to those seen in other patients; it is uncommon to find the large hematomas or joint bleeds characteristic in patients with severe hemophilia

  • Female patients may present with vaginal spotting or bleeding during early pregnancy, preceding a spontaneous miscarriage

  • Persistent, delayed, or recurrent bleeding may occur at sites of trauma or surgery

  • Poor wound healing may be noted

  • Acquired causes of FXIII deficiency, such as DIC and liver disease, present in a well-recognized manner

See Clinical Presentation for more detail.

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