How is pediatric multiple sclerosis (MS) differentiated from acquired demyelinating disorders of the CNS?

Updated: Jan 30, 2019
  • Author: Alice K Rutatangwa, DO, MSc; Chief Editor: Amy Kao, MD  more...
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In general, atypical features of pediatric multiple sclerosis (MS) include fever, encephalopathy, progressive symptoms or disease course, other organ system involvement (including the peripheral nervous system), absence of CSF OCBs, elevated IgG index, and markedly elevated CSF leukocytes. [37] The more atypical features present and the younger the child, the more consideration necessary prior to diagnosing MS.

A thorough history and physical examination, serum and CSF testing, and neuroimaging will likely provide the diagnostic specificity desired to differentiate between acquired demyelinating disorders of the CNS in children and the other disorders.

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