Which factors may affect the reliability of fructosamine test results?

Updated: Oct 01, 2019
  • Author: Justyna Kotus, MD; Chief Editor: Eric B Staros, MD  more...
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All conditions that affect serum albumin production (eg increased or decreased turnover) may affect the reliability of fructosamine assay, such as the following:

  • Hepatic diseases (eg, cirrhosis)

  • Nephrotic syndrome

  • Thyroid disease

  • Paraproteinemia

High levels of ascorbic acid interfere with the fructosamine assay. Patients should abstain from ascorbic acid supplements for a minimum of 24 hours prior to sample collection.

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