What are indications for fructosamine testing?

Updated: Oct 01, 2019
  • Author: Justyna Kotus, MD; Chief Editor: Eric B Staros, MD  more...
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Testing of serum fructosamine is indicated for monitoring of glycemic control in the following circumstances:

  • Effect of the change (< 6 wk) in diet, exercise, or medication

  • When a narrow time frame is required, such as for ascertaining glycemic control at the time of conception in diabetic women who recently became pregnant

  • Conditions in which HbA1c may be unreliable, such as hemoglobinopathy (eg, sickle cell disease), hemolytic anemia, or recent blood loss

A study by Mendes et al indicated that in pregnant women with gestational diabetes mellitus, neonatal complications, as well as newborn respiratory disorders, are more likely to exist in the presence of higher maternal fructosamine and glycated albumin levels. According to the investigators, these glycemic markers are better indicators of these complications than HbA1c. [5]

A study by Connor et al involving Hispanic and non-Hispanic white women with invasive breast cancer found the mortality risk to be higher in the presence of diabetes and elevated fructosamine levels. The likelihood of all-cause mortality was more than twice as great, and the risk of breast cancer–related death over four times higher, in study subjects with raised fructosamine than in those with normal levels. [6]

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