What is the relationship between hemoglobin A1c (HbA1c) and fructosamine?

Updated: Oct 01, 2019
  • Author: Justyna Kotus, MD; Chief Editor: Eric B Staros, MD  more...
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The half-life of hemoglobin A1c (HbA1c) is much longer than that of albumin (the half-life of a red blood cell is 120 d), and glycohemoglobin measurement reflects average glycemic control over 3-4 months. [4] HbA1c and fructosamine are highly correlated. The relationship between the fructosamine level and the HbA1c level can be present as a linear regression analysis, [4] as follows:

  • HbA1c = 0.017 X fructosamine level (µmol/L) + 1.61

In practice, fructosamine testing refers to a laboratory test for diabetes management that it is rarely used in clinical practice (simple blood glucose monitoring or HbA1c testing are preferred). However, the main advantage of the test is that it can detect overall changes in blood glucose control within a few weeks, rather than months (like HbA1c). Fructosamine can be also useful when the HbA1c measurement may be unreliable.

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