What is fructosamine?

Updated: Dec 26, 2018
  • Author: Justyna Kotus, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Serum fructosamine is formed by nonenzymatic glycosylation of serum proteins, predominantly albumin. [1, 4] The degree of protein glycation is proportional to the concentration of plasma glucose over the lifetime of the protein. Albumin, the most common serum protein, typically accounts for 80% of all fructosamine. Because a half-life of serum albumin is 14-21 days, serum fructosamine generally reflects the state of glycemic control for the preceding 2-3 weeks.


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