How are the results of Lp(a) measurement interpreted?

Updated: Aug 05, 2019
  • Author: Abimbola Farinde, PharmD, PhD; Chief Editor: Eric B Staros, MD  more...
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Many US lipidologists consider a Lp(a) level < 10.0 mg/dL to be indicative of lower cardiovascular risk, with higher levels associated with an increase in cardiovascular risk. [1]

As noted by Davidson, the odds ratio for significant coronary heart disease on angiography in patients with a Lp(a) level greater than 30 mg/dL versus a level less than or equal to 5 mg/dL increased from 1.67 to 6.0, as LDL concentrations increased as well. [2]

In addition, a number of prospective trials have demonstrated that Lp(a) predicts risk in a nonlinear fashion; thus, increases in cardiovascular risk are extremely small until Lp(a) levels are within the top 5-10%. [3, 4]

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