What are the indications for apolipoprotein B (apoB) measurement?

Updated: Aug 02, 2019
  • Author: Georges Elhomsy, MD, ECNU, FACE; Chief Editor: Eric B Staros, MD  more...
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Incontestable data support the concept that apoB is a better tool to assess cardiovascular disease than LDL-C and non-DHL-C.

Furthermore, apoB seems to be a very important parameter in assessing cardiovascular risk in the setting of diabetes and metabolic syndrome, since patients with these conditions tend to have small, dense LDL particles with relatively normal LDL-C but high apoB levels.

In addition, several clinical trials have shown that apoB is a better marker for monitoring patients on statin therapy for residual risk than LDL-C.

Finally, a Consensus Conference Report by the ADA/ACC has recommended the use of apoB level for risk assessment in persons at high risk for cardiometabolic disease.

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