What is the reference range of apolipoprotein B (apoB)?

Updated: Jul 08, 2021
  • Author: Georges Elhomsy, MD, ECNU, FACE; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. [1]

The reference range of apoB levels in adults is less than 130 mg/dL (1.3 g/L).

ApoB levels are higher in males than in females and tend to increase with age.

It has been suggested the range be adjusted according to the risk factor stratification, [2] similar to low-density lipoprotein cholesterol (LDL-C).

Table 1.  Treatment Goals for Total ApoB Relative to LDL-C Levels (Open Table in a new window)

Risk

ApoB

LDL-C

High risk: CHD or CHD risk equivalent

< 90 mg/dL

< 100 mg/dL

Moderate risk: ≥2 risk factors

< 110 mg/dL

< 130 mg/dL

Low risk: 0-1 risk factors

< 130 mg/dL

< 160 mg/dL

CHD, coronary heart disease

 

Table 2. ADA/ACC Consensus Report Treatment Goals in Patients with Cardiometabolic Risk and Lipoprotein Abnormalities [3] (Open Table in a new window)

Risk

ApoB

LDL-C

Non-HDL-C

Highest-risk patients: Known CVD or DM plus ≥1 additional major CVD risk factor

< 80 mg/dL

< 70 mg/dL

< 100 mg/dL

High-risk patients: ≥2 CVD risk factors but no DM or known CVD or DM but no other major risk factors

< 90 mg/dL

< 100 mg/dL

< 130 mg/dL

CVD, cardiovascular disease; DM, diabetes mellitus; non-HDL-C, non–high-density lipoprotein cholesterol


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