What are the indications for apolipoprotein A-I (Apo-A1) measurement?

Updated: Aug 02, 2019
  • Author: Georges Elhomsy, MD, ECNU, FACE; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Because it is not clear whether Apo-A1 is an independent predictor of cardiovascular disease, it may be useful to be measured in conjunction with Apo-B to assess the Apo-B/Apo-A1 ratio.

A higher ratio means an increased likelihood of cholesterol deposition in arteries, leading to atherosclerosis and a higher risk of cardiovascular disease.

A study by Henson et al indicated that in patients with coronary artery disease, low levels of immune complex consisting of Apo-A1 and immunoglobulin G (IgG) are an independent risk factor for adverse cardiovascular events. Thus, according to the investigators, this immune complex may represent a potential biomarker for predicting cardiovascular disease progression. [6]

Apo-A1 is one of many serum markers used in the fibroTest, a noninvasive assessment of the liver that was validated in many liver disease, including hepatitis C, hepatitis B, nonalcoholic fatty liver disease, and alcoholic liver disease.


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