Which assays are used to measure rheumatoid factors (RFs)?

Updated: Jan 28, 2021
  • Author: Tyler Street, MD; Chief Editor: Eric B Staros, MD  more...
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Rheumatoid factor (RF) has historically been measured with all the following assays: Agglutination of sheep RBCs that have been sensitized with rabbit IgG, radioimmunoassays and enzyme immunoassays, and agglutination of polystyrene latex particles coated with human IgG. No assay has been proven to be better than another, and, lack of standardization between tests leads to variability in results.

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