What are limitations of a 24-hour concentrated urine sample for immunofixation testing?

Updated: Jul 29, 2019
  • Author: Anastasios Dimou, MD; Chief Editor: Eric B Staros, MD  more...
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A 24-hour concentrated urine sample is appropriate for urine immunofixation. This sample is often difficult to collect, and suboptimal collection might alter the result. A concomitant measurement of the creatinine in the 24-hour urine sample for correction of sampling errors has been proposed. [18, 19]

Detection of a paraprotein by immunofixation is possible in lymphomas. [14]

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