What are considerations regarding immunofixation results in multiple myeloma?

Updated: Jul 29, 2019
  • Author: Anastasios Dimou, MD; Chief Editor: Eric B Staros, MD  more...
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A negative urine or serum immunofixation result does not always rule out a plasma cell dyscrasia, as a nonsecretory or oligosecretory multiple myeloma can present with a negative immunofixation finding in both the urine and the serum. A serum free light chain ratio is indicated in the case of a negative immunofixation result when the suspicion for multiple myeloma is still high. [10, 17]

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