Why is von Willebrand factor (vWF) multimer analysis performed?

Updated: Aug 01, 2019
  • Author: Carlos Solano Loran, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

The plasma von Willebrand factor (vWF) multimer analysis provides a qualitative visual assessment of the size spectrum and the banding pattern of VWF multimers present in plasma compared with a normal control.

This test allows identifying qualitatively abnormal variants of the vWF, also known as type II von Willebrand disease (vWD). vWF multimer analysis using low- and medium-resolution gels clearly distinguishes abnormal banding patterns that result from atypical vWF structures and allows their classification as vWD type IIA, IIB, IIM, or IIN and their different subtypes (eg, IIA, IIB, IIC, IIC, IIE, and IID). [2]


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