How are the types of inherited von Willebrand factor (vWF) deficiency classified?

Updated: Nov 05, 2019
  • Author: Vadim Kostousov, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Type 1 vWD: Decreased vWF antigen (vWF:Ag) and vWF ristocetin cofactor (vWF:RCo) levels (vWF:RCo/vWF:Ag ratio >0.7)

Type 2 vWD: vWF:Ag that is largely normal or mildly decreased, with vWF:RCo of less than 30-40% (vWF:RCo/vWF:Ag ratio < 0.7), is typical for vWD 2A and 2B

Type 3 vWD: Severe deficiency or absence (both vWF:Ag and vWF:RCo < 5%)


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