What causes acquired von Willebrand factor deficiency?

Updated: Feb 12, 2020
  • Author: Vadim Kostousov, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Autoimmune clearance or inhibition causes are as follows:

Causes of vWF deficiency due to increased shear-induced proteolysis are as follows:

Other causes include the following:

  • Drug-induced (hydroxyethyl starch, valproic acid)

  • Myeloproliferative diseases (polycythemia, thrombocythemia)

  • Angiodysplasia, glycogen storage disease

Increased vWF:RCo activity and increased vWF:Ag are observed in acute phase reactions, which can be associated with the following:

  • Stress, extensive exercise

  • Inflammation

  • Cancer

  • Obesity

  • Postoperative period

  • Diabetes

  • Atherosclerosis and atherothrombosis

  • Pregnancy


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