What causes inherited von Willebrand factor deficiency?

Updated: Feb 12, 2020
  • Author: Vadim Kostousov, MD; Chief Editor: Eric B Staros, MD  more...
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See the list below:

  • Type 1 - Decreases are noted in both von Willebrand factor (vWF) antigen (vWF:Ag) and vWF ristocetin cofactor (vWF:RCo) levels (vWF:RCo to vWF:Ag ratio > 0.7).

  • Type 2 - Decrease only noted in vWF:RCo levels. vWF:Ag levels are largely normal (vWF:RCo to vWF:Ag ratio < 0.7) in von Willebrand disease (vWD) types 2A and 2B but vWF:RCo may be normal or decreased in types 2N and 2M.

  • Type 3 - Severe deficiency or absence of both vWF:RCo and vWF:Ag (< 5%).

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