How should a shortened activated partial thromboplastin time (aPTT) be interpreted?

Updated: Jul 30, 2019
  • Author: Muhammad Bader Hammami, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

A shortened aPTT result may indicate the following [1, 2] :

  • Early stages of DIC: circulating procoagulants exist in the early stages of DIC, shortening the aPTT

  • Extensive cancer (eg, ovarian cancer, pancreatic cancer, colon cancer)

  • Immediately after acute hemorrhage

  • An acute-phase response leading to high factor VIII levels


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