What is a protein Z/protein Z–dependent protease inhibitor?

Updated: Feb 07, 2020
  • Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP; Chief Editor: Eric B Staros, MD  more...
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Protein Z/protein Z–dependent protease inhibitor

Coagulation factors XIa and Xa are inhibited by ZPI, an Mr 72,000 serine protease inhibitor. The presence of protein Z, a vitamin K–dependent plasma protein, increases its inhibition of factor Xa over 1000-fold. [10] Protein Z/ZPI's physiologic activity in the coagulation system is unclear.

In a mouse model, protein Z deficiency does not cause thrombosis, but it does significantly increase the thrombotic tendency of mice who simultaneously express the factor V Leiden genotype, a known thrombotic risk factor. [11]

The protein Z gene exists on the long arm of chromosome 13, where it lies in close proximity to the genes for factor X and factor VII. [12]

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