What causes a decrease in factor XIII?

Updated: Feb 07, 2020
  • Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Decreases in factor XIII levels occur in association with the following:

  • Inheritance (severe bleeding in homozygous carriers)

  • Liver disease

  • Acute promyelocytic leukemia

  • Autoantibodies against factor XIII (presence of circulating inhibitors)


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