What are the limitations of a factor X assay?

Updated: Feb 06, 2020
  • Author: George Ansstas, MD; Chief Editor: Eric B Staros, MD  more...
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Limitations of factor X testing include the following:

  • Partially clotted specimens due to poor mixture of anticoagulant (3:2 sodium citrate, as per manufacturer’s blue-topped tube)

  • Overfilled or underfilled test tubes (altering the ratio of blood to anticoagulant [9:1])

  • Improperly stored plasma

  • Contamination with heparin or dilution of collected sample if indwelling catheters are used

  • Analytical errors such as lipemic, icteric, or hemolyzed plasma, which may interfere with photoelectric measuring instruments [14]

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