What causes a decrease in factor X?

Updated: Feb 06, 2020
  • Author: George Ansstas, MD; Chief Editor: Eric B Staros, MD  more...
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Inborn deficiency of factor X is very uncommon (1 in 500,000 persons). Factor X deficiency may also occur in amyloidosis, in which factor X is adsorbed to the amyloid fibrils in the vasculature. [2, 3] Decreased factor X levels are also associated with vitamin K deficiency, warfarin therapy, severe liver disease, and disseminated intravascular coagulation.

Decreased factor X levels have also been found in myeloma, children with severe burns, Mycoplasma pneumonia infections, patients with lupus anticoagulants, leukemia, and other neoplastic diseases. [4]

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