What causes a decrease in factor IX?

Updated: Feb 04, 2020
  • Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP; Chief Editor: Eric B Staros, MD  more...
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The following are associated with decreases in factor IX [3] :

  • Hemophilia B

  • Liver disease

  • Use of vitamin K antagonists (eg, warfarin) or vitamin K deficiency

  • Amyloidosis

  • Nephrotic syndrome

  • Alloantibodies in hemophilia B patients treated with factor IX infusions

  • Autoantibodies to factor IX in previously healthy individuals (extremely rare)

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