What are the limitations of a factor VII assay?

Updated: Feb 05, 2020
  • Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP; Chief Editor: Eric B Staros, MD  more...
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Limitations of the test include partially clotted specimens due to poor mixture of anticoagulant (3:2 sodium citrate as per manufacturer’s blue-topped tube), overfilled or underfilled test tubes altering the ratio of blood to anticoagulant (9:1); improperly stored plasma; contamination with heparin or dilution of collected sample if indwelling catheters are used; or analytical errors such as lipemic, icteric, or hemolyzed plasma, which may interfere with photoelectric measuring instruments. [12]

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