What is the reference range for factor VII?

Updated: Feb 05, 2020
  • Author: Bishnu Prasad Devkota, MD, MHI, FRCS(Edin), FRCS(Glasg), FACP; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

Factor VII circulates as a single-chain zymogen of molecular weight of about 50,000 daltons. It has the shortest half-life of the procoagulant factors, approximately 3-6 hours. [1] The human factor VII gene is located on chromosome 13, very close to the gene for factor X. [1] Embryos deficient in factor VII developed normally without evidence of hemorrhage. Nevertheless, factor VII-deficient newborns sometimes develop fatal intra-abdominal or intracranial hemorrhage. [2]

The reference range for factor VII is 65-140% of normal. [3]


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