What is the role of D-dimer measurement in the workup of deep venous thrombosis (DVT)?

Updated: Nov 18, 2019
  • Author: Reka G Szigeti, MD, PhD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

In adult patients with a clinically low pretest probability (Wells score) of developing DVT, a negative D-dimer test result yields a 99% negative predictive value (NPV) in patients aged 60-80 years but only a 21%-31% NPV in patients older than 80 years. [5]

In patients with a clinically high pretest probability (Wells score) of developing DVT, the D-dimer test has essentially no clinical utility. [6] Anticoagulant therapy is initiated regardless of test result. [5]

In pregnant patients, a negative D-dimer test results has a NPV of 100%.


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