How are epithelioid angiosarcoma and malignant SFT differentiated?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

Answer

Another diagnostic challenge is the distinction between epithelioid angiosarcoma and malignant fibrous tumor (see above). Malignant SFT usually presents as a localized mass but rarely spreads within the pleura in a diffuse fashion. Malignant fibrous tumors histologically have a spindle cell appearance compared to the epithelioid appearance of EHE or angiosarcoma. While both malignant fibrous tumor and EHE/epithelioid angiosarcoma are negative for cytokeratin and positive for CD34, malignant fibrous tumors lack staining for the more specific endothelial markers CD31 and factor VIII.


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