How is lymphoma differentiated from pleural desmoplastic small round cell tumor (DSRCT)?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

Answer

Lymphoma generally occurs in a sheetlike infiltrating pattern and lacks the nesting pattern, cell cohesion, and fibrous stroma of DSRCT. Furthermore, lymphomas express characteristic lymphoid markers immunohistochemically and are negative for keratin and muscle and neuroendocrine markers. Primary pleural lymphomas are rare but have a poor prognosis. [2]


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