How is small cell neuroendocrine carcinoma differentiated from pleural desmoplastic small round cell tumor (DSRCT)?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

Answer

Small cell neuroendocrine carcinoma demonstrates similar histologic features as DSRCT, but without a prominent fibrous stroma. Small cell carcinoma is, however, a tumor of older individuals and is highly associated with tobacco smoke exposure. Small cell carcinoma is positive for cytokeratin and a wide range of neuroendocrine markers, but, unlike DSRCT, small cell carcinoma is positive for TTF1 and lacks staining for desmin.


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