How is malignant solitary fibrous tumors (SFTs) of the pleura staged?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

Answer

A staging system of pleuropulmonary SFTs, based on common clinicopathologic criteria, proposed by de Perrot et al includes the following stages: [85]

  • Stage 0: Tumor with peduncle without features of malignancy at histology

  • Stage 1: Tumor with sessile or "inverted" appearance without features of malignancy at histology

  • Stage 2: Tumor with peduncle with features of malignancy at histology

  • Stage 3: Tumor with sessile or inverted appearance with features of malignancy at histology

  • Stage 4: Multiple metastatic tumor

The de Perrot staging system was assessed independently by Schirosi et al and shown to correlate statistically, on univariate analysis, with the most important clinicopathologic prognostic parameters in SFTs. Tumor stage also correlated with overall survival and disease-free survival (P< 0.001). [10]


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