What is the role of genetic studies in the diagnosis of pseudomesotheliomatous carcinoma?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

There are few studies of molecular or genetic alterations in pseudomesotheliomatous lung adenocarcinoma. In 4 cases, Pardo et al reported a median of 15 chromosomal imbalances per case using a comparative genomic hybridization technique. [57] In this study, the most frequent aberrations were gains on chromosome regions 1q, 3q, 5p, 8q, 16p, and 18q and losses in 17p11-13 and 17q22-q25. All cases showed a characteristic association between the gains on 16p and those on 18q. [57]

Further molecular and genetic studies are required to discern if there are consistent molecular markers of pseudomesotheliomatous adenocarcinoma that distinguish it from usual non–small cell lung carcinoma or malignant mesothelioma.


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