Which immunohistochemistry findings are characteristic of primitive neuroectodermal tumor of the thoracopulmonary region (PNET)?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

PNETs consistently stain immunohistochemically for vimentin and CD99. PNETs usually stain for neuron specific enolase and stain variably for other neuronal markers such as S100, synaptophysin, chromogranin, and glial fibrillary acidic protein. Although usually negative for keratin, PNETs may stain focally for keratin, EMA, and desmin. CD99 is regarded as the most useful immunohistochemical marker, staining in a cell membrane pattern. However, CD99 is not specific for PNET and must be interpreted in conjunction with other immunohistochemical markers and with the clinical and histological features of the case. [29, 44]

Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. This image demonstrates immunostaining for vimentin.
Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. This image demonstrates immunostaining for CD99.
Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. This image demonstrates immunostaining for glial fibrillary acidic protein (GFAP).

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