Which immunohistochemistry findings are characteristic of pleural desmoplastic small round cell tumor (DSRCT)?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Answer

DSRCT typically expresses divergent staining for epithelial, mesenchymal, and neuroendocrine markers. [15, 67] The most frequently positive immunostains include diffuse staining for cytokeratins, EMA, and vimentin; dotlike cytoplasmic staining for desmin; and nuclear staining for the carboxy-terminal end of WT-1. [15, 76]

DSRCTs also frequently stain for neuron specific enolase (NSE), BerEp4, and CD15. [15] Rarely, DSRCT may lack epithelial immunohistochemical markers. [77]

Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. Tumor cells positive for cytokeratin are indicative of epithelial differentiation.
Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. Discrete, "dot-like" positivity for desmin is a manifestation of mesenchymal differentiation.
Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. Immunostaining for neuron specific enolase (NSE) indicates neuroendocrine differentiation.

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