Which histologic findings are characteristic of pseudomesotheliomatous carcinoma?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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The histological features of pseudomesotheliomatous lung adenocarcinoma are usually described as simple tubular or acinar structures surrounded by a dense collagenous stroma, an appearance termed "tubulo-desmoplastic" by Hammar and Dodson. [24] Papillary or tubupapillary epithelial configurations, signet ring cells, and poorly differentiated carcinoma have also been described. [56, 53, 57, 58] Mucin is frequently detectable on mucicarmine, periodic acid Schiff (PAS) or Alcian blue (resistant to hyaluronidase digestion) stains.

Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. Pseudomesotheliomatous lung adenocarcinoma. Invasive adenocarcinoma with fibrocollagenous desmoplastic reaction infiltrates the diaphragm (upper layer) and atelectatic lung (lower).
Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. This micrograph reveals an acinar and papillary focus of adenocarcinoma surrounded by desmoplastic stroma.
Pathology of nonmesothelial cancers of the pleura. Pathology of nonmesothelial cancers of the pleura. Tubulodesmoplastic pattern of infiltrating adenocarcinoma. Red-staining intracytoplasmic mucin in tumor cells is a feature that distinguishes adenocarcinoma from epithelioid mesothelioma (periodic acid Schiff stain with diastase predigestion).

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