Which clinical history findings are characteristic of malignant solitary fibrous tumors (SFTs) of the pleura?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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SFTs are usually asymptomatic and present as mass lesions on thoracic imaging. Systemic symptoms may include fever, fatigue, night sweats, and weight loss. Owing to their intrathoracic location, SFTs may be associated with symptoms of cough, chest pain, and dyspnea. Large tumors may produce digital clubbing, hypertrophic osteoarthropathy (Pierre-Marie-Bamberg syndrome), or hypoglycemia (Doege-Potter syndrome) due to the secretion of insulinlike growth factor II. Hypoglycemia is more frequently seen in females. [3, 9, 10]

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