What is the prevalence of pseudomesotheliomatous carcinoma?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Most pseudomesotheliomatous carcinomas of the pleura are thought to arise from occult peripheral adenocarcinomas of the lung. However, metastases from various sites, such as kidney, thyroid, larynx, stomach, and cutaneous melanoma or Merkel cell carcinoma have been described as simulating malignant mesothelioma. [3, 35] Metastatic soft-tissue sarcomas may also spread to the pleura and mimic mesothelioma. The distinction between metastatic sarcomatoid renal cell carcinoma and sarcomatoid mesothelioma is particularly problematic.

Besides adenocarcinoma, which accounts for 70% of pseudomesotheliomatous pulmonary carcinomas, other primary lung cancers, including squamous cell carcinoma, small cell carcinoma, large cell carcinoma, and carcinosarcoma may also present as a pseudomesotheliomatous tumor. [3, 36]

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