What is pleural synovial sarcoma?

Updated: Dec 25, 2019
  • Author: Joseph F Tomashefski, Jr, MD; more...
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Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. The histogenesis of synovial sarcoma is unknown. It has not been proven to arise from synovium.

Synovial sarcomas have been described in many anatomic sites. Within the thorax, synovial sarcoma has been reported in the mediastinum, heart and pericardium, lung, and pleura. Overlapping lung and pleural involvement in individual cases has given rise to the more inclusive term “pleuropulmonary” synovial sarcoma. Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. [3, 8]

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