What is the role of immunohistochemistry in the diagnosis of lung transplantation-related pathology?

Updated: Jun 06, 2019
  • Author: Aliya N Husain, MBBS, MD; Chief Editor: Philip T Cagle, MD  more...
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Answer

Answer

In most cases, the diagnosis of acute and chronic rejection of a lung transplant is made on hematoxylin and eosin (H&E)-stained sections.

The role of C4d immunostaining for antibody-mediated rejection in the lung remains controversial. [10]

Immunostaining for lymphocyte markers (B- and T-cells) and in situ hybridization for Ebstein-Barr virus (EBV) mRNA (EBER) and cytomegalovirus (CMV) may be performed as appropriate.


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