How is tissue obtained for histologic evaluation of lung transplantation-related pathology?

Updated: Jun 06, 2019
  • Author: Aliya N Husain, MBBS, MD; Chief Editor: Philip T Cagle, MD  more...
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Answer

Answer

In the explanted lung, the classic findings of the primary disease are readily apparent; in addition, there may be superimposed foci of acute inflammation, organizing pneumonia, and mucostasis.

In the transplanted lung, material for histologic evaluation is obtained via transbronchial biopsy and is analyzed after formalin fixation and paraffin processing. Tissue is obtained either as part of surveillance protocols or as clinically indicated by the new onset of symptoms.

This section describes microscopic findings of the following lung transplantation–related pathologies:

  • Lung allograft rejection

  • Infection

  • Posttransplant lymphoproliferative disease (PTLD)


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