What are the signs and symptoms of pulmonary alveolar proteinosis (PAP)?

Updated: Dec 18, 2019
  • Author: Rodolfo Laucirica, MD; Chief Editor: Philip T Cagle, MD  more...
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The onset of clinical disease is usually insidious, with a varying presentation and nonspecific symptoms, which may delay the diagnosis of PAP by months to years. Most patients experience progressive dyspnea and dry cough. [1] White sputum production, weight loss, hemoptysis, and fever have also been described in patients with PAP. [14, 27, 28] Patients with the congenital form of PAP (see Etiology and Pathophysiology) usually present with an acute onset of rapidly progressive respiratory distress immediately after birth. [14]

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